News
2024
5.11.2024
We were awarded an Amsterdam UMC Starter Grant to pursue our work on unraveling the functions of tRNA dysregulation in glioblastoma!
17.09.2024
Today, Chantal successfully defended her thesis entitled:
Congratulations Dr Scheepbouwer!!!
16.09.2024
Welcome to Min who joined us as a PhD student! Min will work on the identification of cis-regulatory regions and transcription factors involved in the regulation of tRNA genes in the context of our shared ZonMW project with the van Leeuwen lab at the NKI.
1.07.2024
Welcome to Omar who joined us for a master internship. Omar will work together with Chantal on the pharmacological targeting of tRNA functions in glioblastoma.
14.05.2024
The vast majority of tRNAs in cells harbor a 3' CCA tail, essential for amino acid loading. Chantal found that in EVs, full-length tRNAs lacking an intact CCA are the most abundant small RNAs => EVs as tiny tRNA trash bags😉? Check out Chantal's preprint on bioRxiv!
26.04.2024
A great review on the interplay between chromatin and the regulation of RNA Pol III-dependent genes written by Marlize (van Leeuwen lab) just appeared online in Biochemical Society Transactions!
03.04.2024
Our project 'Decoding the emerging role of dynamic tRNA gene regulation in cancer and cellular adaptions to changing environments' in collaboration with the group of Prof Fred van Leeuwen at the NKI is among the 29 innovative collaborative research projects funded by ZonMW in the 2023 Open Competition round! More info here or here. Two PhD positions will be open soon (1 at the NKI, 1 at Amsterdam UMC - CCA).
05.02.2024
Welcome to Yvette who joined us for a master internship. Yvette will work on the reciprocal regulation between a protein-coding and a tRNA gene under the supervision of Boris.
2023 ▼
29.06.2023
Boris wins the best poster award of OddPols 2023, the International Conference on Transcription Mechanism and Regulation by archaeal RNA Polymerases and eukaryotic RNA Polymerases I, III, IV, and V that took place in Jaen (Spain).
Congrats to Boris!
26.05.2023
Trisha wins 2nd best poster prize at the VU Biomedical Sciences bachelor poster day! Congrats to Trisha (and her daily supervisor Boris!)
22.05.2023
Chantal strikes again! Congrats to Cristina (Exosome Research Group) and Chantal on the publication of the NORMSEQ manuscript in NAR! NORMSEQ, a tool for evaluation, selection and visualization of RNA-Seq normalization methods, is available here.
13.02.2023
Our review, written in collaboration with Evelina Tutucci, Sander van Otterdijk and Frank Bruggeman (VU Amsterdam, Systems Biology lab), on Understanding spatiotemporal coupling of gene expression using single molecule RNA imaging technologies is online!
22.02.2023
Chantal's manuscript on the development of ALL-tRNAseq for the robust profiling of tRNA expression in tissue samples is online on the Genes & Development website! Congrats to Chantal!
06.02.2023
Welcome to Maurice and Trisha who joined us for their master and bachelor internship respectively.
2021-2022 ▼
01.09.2022
Welcome to Fraser Johnson! Fraser joins the group as a Post-doc to work on the development of a screening procedure to identify oncogenic RAS inhibitors.
21.12.2021
We received a KWF (Dutch Cancer Society) grant for our project 'Finding the key to inactivate oncogenic RAS mutants'! More info
09.12.2021
Our project 'Precision targeting of aminoacyl-tRNA-synthetase in cancer' is among the 9 projects funded by the Cancer Center Amsterdam Foundation!
More info here and here